Abstract :
Introduction: Codon 72 polymorphism (G> C; Arg> Pro) in p53, an important tumor suppressor gene, contribute to an elevated risk of many cancers including breast cancer. p53 alterations negatively impact cell cycle arrest, DNA damage repair, and apoptosis leading to cancer onset and development. The occurrence of p53 exon 4 G>C polymorphism is different in diverse populations, but the information regarding its allelic distribution in the Saudi population is lacking.
Methods: PUBMED (Medline), the web of science and google database were used to search
epidemiological studies conducted globally to compare the frequency distribution of variant allele in the Saudi population with that of diverse ethnic groups.
Results: The frequency of p53 exon 4 variant allele (G) was found to be 51% in the Saudi population. A significantly different variant allele frequency was found for Japan (p
Keyword :
p53 Arg72Pro; Single Nucleotide Polymorphism (SNP); Minor Allele Frequency (MAF); Saudi Arabia