Volume :

5

Issue :

1

Abstract :

Objective Cefuroxime axetil is a second generation cephalosporin antibiotic active against wide range of organisms, which is a prodrug of Cefuroxime. Cefuroxime axetil is extremely bitter in taste, which reduces the patient compliance when taken as oral suspension especially in pediatric population. The objective of this study was to mask the bitter taste of Cefuroxime axetil using Hydroxy propyl betacyclodextrin [HP- Betacyclodextrin] by inclusion complexation method and to evaluate the improvement in antimicrobial activity of oral suspension, compared to a leading marketed product. Methods The complexation of Cefuroxime axetil and HP- Betacyclodextrin was carried out at 1:1, 1:2, 1:2.5 and 1:3 ratios respectively. The prepared suspension was evaluated for various parameters like pH, viscosity, redispersibility, pourability, assay and invitro dissolution profile. Comparative evaluation of the taste masking and antimicrobial sensitivity tests were carried out for the developed formulations and marketed product. Results All the formulations and the marketed product were meeting all the quality parameters. Formulations with 1:3 and 1:2.5 ratios showed better taste masking compared to the marketed product and the formulation with 1:2.5 ratio shown to have better invitro dissolution pattern. The optimized formulation was found to have better antimicrobial activity against selected organisms compared to the marketed product. Conclusion Considering the invitro dissolution profile and taste evaluation with marketed product, formulation with 1:2.5 ratio of Cefuroxime axetil and HP- Betacyclodextrin was selected as the optimum formulation, which also demonstrated improved antimicrobial activity.