Abstract :
Five coordination compounds of Cu(II), Ni(II), Co(II), Mn (II) & Fe(III) with bidentate ligand derived from
3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione (dehydroacetic acid) & 4- isopropyl benzaldehyde, were synthesized &
characterized by elemental analysis, TGA-DTA analysis, magnetic susceptibility, UV-visible, IR, 1H-NMR
spectroscopy, Mass & antimicrobial activity. From the analytical & spectral data, the stoichiometry of these
coordination compounds was found to be 1:2 (metal: ligand). The physic-chemical data propose a distorted
octahedral and octahedral geometry for the Cu (II) and all the other complexes respectively. The thermal analysis of
all the prepared coordination compounds was studied by the TG-DTA method. The synthesized ligand and its
coordination compounds were evaluated for their in vitro antimicrobial activity against Gram-negative (Shigella
boydii) and Gram-positive (Bacillus Cereus) bacterial strains and against Saccharomyces Cerevisiae and Penicillium
notatum antifungal strains. It is observed that some of the coordination compounds are antimicrobial active & show
higher potency than the sole ligand. Complex formation changes significantly the antibacterial as well as antifungal/
bioactive behavior of the sole ligands.
Keyword :
Dehydroacetic acid, Transition metal complexes, Chalcone, Antimicrobial activity.