Volume :

5

Issue :

4

Abstract :

The conventional methodology was adopted to synthesize the novel substituted pyrazole derivatives from substituted chalcone derivatives as starting material. The intermediate chalconederivatives(II) were prepared from reaction between equimolar quantities of substituted Aromatic aldehydes (0.01mol) and acetophenone(I) (0.01mol) in the presence of sodium hydroxide solution(0.02mol) using ethanol as solvent. The novel pyrazole derivatives were synthesized by means of cyclization reaction between equimolar quantities of substituted chalcone intermediates (0.02 mol) and hydrazine hydrate (0.02 mol) using sodium acetate in ethanol as solvent. All the synthesized derivatives were characterized by Infrared pectroscopy(IR), Mass spectroscopy(MS) and proton nuclear magnetic resonance(1H NMR). All the pyrazole derivatives were screened for anti bacterial activity by disc diffusion method against the organisms, S.aureus and E.coli. The derivatives are also screened for Antifungal activity using Candida albicans by double dilution method on nutrient agar media. The standard drug used was Ampicillin for anti-bacterial and Ketoconazole for anti-fungal activity.