Volume :
3
Issue :
1
Abstract :
Mannich bases of benzotriazoles were synthesised and are evaluated for invitro anticancer studies. Different active hydrogen compounds were selected and are reacted with benzotriazole and formaldehyde; with the removal of water molecule the desired mannich bases are obtained. The synthesised compounds were then established on the basis of IR and 1HNMR spectral data and screened for anticancer activity on Human colorectal adenocarcinoma (HCT116) and on Human breast cancer cell line (MDA-MB-468). The derivatives showed moderate activity on both cell lines.