Volume :
2
Issue :
3
Abstract :
Some novel compounds are synthesized with the reaction between o-hydroxy actephenone and 1H-indole 3-carbaldehyde. Completion of reaction was monitored on TLC using silica gel-G coated plates by using Hexane: ethyl acetate (3:2) as the eluent and observed in the UV light. In this manner 10 novel compounds are prepared and subjected to biological screening. The newly synthesized compounds were characterized using IR, 1H-NMR. Anti oxidant activity is determined by nitric oxide radical scavenging activity and hydrogen peroxide scavenging activity. Anti oxidant activity revealed that all the synthesized compounds have shown significant anti-oxidant activity when compared with that of standard drug. The compounds 3b, 3c, 3f and 3j showed more activity as compared to the other derivatives. IC50 values were calculated by statistical regression analysis to find out the concentration to show 50% scavenging activity.