Volume :
5
Issue :
2
Abstract :
Pyrazolone is a ketone derivative of pyrazole having anti inflammatory, analgesic, antipyretic effect. Pyrazolone is a five- membered lactam ring compound contacting two nitrogen and ketone in the same molecule. Pyrazolones are well established in literature as important biologically active heterocyclic compounds. Pyrazolone in the class of nonsteroidal anti inflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorder. The objective of present study was, to synthesize the pyrazolone derivatives and to evaluate for their anti-inflammatory activity. Method In the present work, a series of some pyrazolone derivatives (2a-j) were synthesized, characterized by TLC, Melting point determination, IR, NMR and Mass spectra and evaluated for their anti-inflammatory activity by invitro using inhibition of albumin denaturation technique method. Result & Conclusion 2a,2b,2d, Compounds showed significant anti-inflammatory activity as compared to other drug. Aspirin used as a standard drug.