Volume :

2

Issue :

1

Abstract :

A series of novel N-sulphonamido methyl benztriazole derivatives had been synthesized by combining benztriazole, formaldehyde and sulphonamides. Structure of synthesized compounds was elucidated by spectral analysis. Synthesized compounds were evaluated for in-vitro antiviral activity against HIV, HSV and Vaccinia viruses in cell culture. N-Sulphonamido methyl benzotriazole (BT-SN) inhibits Herpes Simplex Virus (HSV) -2 and Vaccinia virus at 34 µg/ml, respectively. HSV-1 at the concentration of 45 µg/ml. The minimum cytotoxic concentration was found to be more than 100µg/ml. So these compounds are suitable for designing newer derivatives and molecular modifications in them may help in optimizing antiviral activity.