Volume :

1

Issue :

1

Abstract :

A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo [1,3] oxazine-4-ones and primary amines. Their chemical structures were assigned by means of spectral analysis (FT-IR and 1H-NMR). Synthesized compounds were screened for in vitro antiviral activity against HIV-1 and -2 replication in MT-4 cells. Cytotoxicity was also investigated in uninfected MT-4 cells (C-type Adult T Leukemia cells). All the synthesized compounds exhibited cytotoxicity in MT-4 cells (CC50: 1.93-87 μg/ml) and compound SPB-III displayed marked cytostatic properties in MT-4 cells (CC50:1.93± 0.29μg/ ml).