Abstract :
Introduction: Obesity is associated with complications like Diabetes, Asthma, Hypertension and cardiovascular risks which are to be managed of health care worldwide. Increased BMI during childhood and adolescence may lead to premature death from disease and may increase the risk of CVD at adult age.
Methods: 30 obese children with an age group of 8-15 years attending paediatric department and 30 healthy age matched non obese children were taken in the study. BMI was calculated for all and biochemical markers like fasting blood glucose, Insulin resistance (HOMA-IR) were determined using commercial enzymatic kits. MDA, FRAP, and NO was determined by chemical methods.
Results: A significant increased levels of BMI, Insulin and insulin resistance (HOMA-IR), MDA and NO levels (P
Keyword :
Paediatric obesity, Endothelial dysfunction, Adipocytokines, Leptin, Vascular smooth muscle cells