Abstract :
Introduction: Insulin resistance always associate pancreatic b -cell dysfunction in type 2 diabetes mellitus.
Obesity is strongly associated with type 2 diabetes mellitus. Therefore screening to evaluate the status of
insulin resistance in offspring of type 2 diabetes mellitus to identify risk of further metabolic complications
is important.
Aims and objectives: The aim of the study is to find out the correlation between insulin resistance in
control with genetic inheritance and obesity.
Materials and Methods: It was a Case control Study carried out on 120 apparently healthy, non-diabetic
people were included in the study. The age of these people lies between 20 to 40 years. The following
anthropometric measurements were done in the above 120 patients. These people were classified depending
upon BMI.
Body Mass Index (BMI) Categorym 18.5–29.99 Non obese 30.0 Obese
Further these people were categorized on the basis of detailed family history of diabetes mellitus to their
parents into 4 different groups and each group contain 30 people as a
a) Group-I (Control): Includes 30 people who were non-obese, off-springs of non-diabetic persons.
b) Group-II (Cases): Includes 30 people who were non-obese, offsprings of type 2 diabetes mellitus
patients.
c) Group-III (Cases): Includes 30 people who were obese, off-springs of non-diabetic persons.
d) Group-IV (Cases): Includes 30 people who were obese, offsprings of type 2 diabetes mellitus.
Conclusion: The purpose of our study was to identify insulin resistance individuals even before appearance
of diabetes mellitus in the above groups by HOM-IR method. So that they can be targeted for aggressive
lifestyle interventions and subsequent morbidity can be prevented.
Keyword :
Insulin resistance, Obesity