Abstract :
Objective: To study some hematological parameters in patients with complicated severe malaria and their
relations to clinical outcome.
Materials and Methods: This was a cross sectional observational study, including 100 patients from
a tertiary care centre in Ghaziabad patients who were diagnosed to have malaria by peripheral smear
examination (both thick and thin smear) or Malaria Rapid Antigen. Blood sample for haematological and
coagulation study were taken.
Results: Out of 100 patients 62 patients had Hb % less than 10 gm percentage in which 14 patients had Hb
< 6>
of the total patients. Packed cell volume was decreased in about 86% of the patients. ESR increase was
seen in 73% of the patient. Thrombocytopenia was observed in 63% of the patients and 25% of the patients
with mixed infection had severe thrombocytopenia. PT and APTT was increased in 22% and 14% of the
total cases. Bleeding time was increased in 5% of the total case and no any patients with vivax malaria had
increased bleeding time. Mixed infection shows as falciparum malaria. Sever anemia, thrombocytopenia,
increase BT, PT and APTT associated to severity and complication of malaria.
Conclusion: This study concluded that hematological changes are common complications encountered in
severe malaria, but they are not related to the clinical outcome.
Keyword :
Severe malaria, Thrombocytopenia, Prothrombin time, APTT.