Abstract :
Introduction:
CRF affects multiple organs of human body like heart and brain. All these effects results due
to dyslipidemia which is due to metabolic and endocrinal disturbances. Electrolyte level alterations
are also observed in case of CRF patients.
Materials and Method:
This cross section study includes total 110 subjects. Out of these 60 subjects were clinically
diagnosed CRF patients having age more than 20 years and remaining 50 subjects were chosen from
healthy controls not having any major medical problem. Among 60 CRF cases, 30 were on
maintenance dialysis for a period of 5 months to 3 years. These patients were undergoing dialysis for
3-4 hours thrice week, Other 30 patients were on conservative line of treatment. Fasting venous
blood samples were collected and serum levels of Total cholesterol, Triglycerides, High density
lipoprotein cholesterol, Low density lipoprotein cholesterol, Very low density lipoprotein cholesterol,
Serum Na+& K+ were measured.
Results:
It is seen that Serum K+, total cholesterol, triglyceride, VLDL-C and total cholesterol to
HDL-C ratio were significantly increased in CRF on conservative management group as compared
controls while mean level of LDL-C did not show any significant difference between these two
groups i.e. controls & CRF on conservative management. The mean value of Serum Na+ and HDL-C
was significantly decreased in CRF on conservative management as compared to control. It is also
observed that Serum K+, total cholesterol, triglyceride, VLDL C and total cholesterol to HDL ratio
were significantly increased in CRF on dialysis group as compared controls while mean level of LDL
did not show any significant difference between these two groups i.e. controls & CRF on dialysis. The mean value of Serum Na+, HDL-C was significantly decreased in CRF on dialysis group as
compared controls.
Conclusion:
The present study indicates that due to dyslipidemia in CRF, there is increased risk of
cardiovascular complications.
Keyword :
Chronic Renal failure, Dyslipidemia, Lipid Profile, Serum Electrolytes.