Volume :
1
Issue :
3
Abstract :
Morinda citrifolia is used in Indian system of medicine for the treatment of variety of diseases and enriched with flavinoids, anthroquinone, glycoside and safe herbal drugs. Present work is to study the effect of ethanolic extract of Noni on various human cell lines to investigate the safety of morinda citrifolia. Morinda citrifolia (MCF-ET) L fruit ethanolic extract have been studied against inhibition of human cell such as HeLa, Vero, HEL and CRFK cells (Crandell-Rees Feline Kidney cells). Cytotoxicity of Morinda citrifolia were investigated by microscopic observation (concentration of extract required to alter normal cell morphology) and tetrazolium based-MTS assay. Ethanolic extract exhibited inhibitory effect on human cells only at high concentration in cells. The ethanolic extract (MCF-ET) displayed cytostatic activity against HeLa and CRFK Cell by both MCPE and MTS assay at the concentration (IC50) of more than 100 µg/ml. Anthroquinone, flavinoid and micronutrients are the principle active constituents of Morinda citrifolia, which may responsible for safety profile of Noni. This result presented herein substantiated the basis for noni exhibits cytotoxicity only at higher concentration and safe herbal drug.