Volume :

1

Issue :

1

Abstract :

Wrightia tomentosa leaf extracts and its isolated compounds (isatin, indirubin and indigotin) have been studied for inhibition of HIV-1 and -2 replication in MT-4 cells. Cytotoxicity was also investigated in uninfected MT-4 cells (C-type Adult T Leukemia cells). All the extracts and isolated compounds exhibited cytotoxicity in MT-4 cells (CC50: 8-117 μg/ml) and Indirubin displayed marked cytostatic properties in MT-4 cells (CC50:8.32±3.83 μg/ ml).