Abstract :
Oestrogen is produced in sizable quantities in the testis, as well as the
brain. Progesterone enhances libido, sperm count, improves mood, and
keeps weight down while increasing muscle mass. This study investigated
some of the effects of oestrogen and progesterone on the testis of adult
male Wistar rats. Twenty (20) adult male wistar rats were randomly
assigned into four groups (A-D) (n=5) and drugs were administered to the
rats as follows: Group A received 1ml of distilled water per day, group B
received 5 mg/kg b.w. of Stilbestrol per day, group C received 0.5 mg/kg
b.w. of Lynestrenol per day while group D received 5 mg/kg body weight
of Stilbestrol and 0.5 mg/kg b.w. of Lynestrenol. Histological, testicular
histomorphometry, hormonal and semen parameters were observed.
Histological evaluations for group (B-D) showed elongated seminiferous
tubules, degeneration of the basement membrane, severe thinning of sertoli cells, reduced number of spermatogenic cells,
wide interstitial space and scanty leydig cells. Biochemical analyses revealed a significant increase (P
Keyword :
Fertility, Stilbestrol, Lynestrenol, testis