Abstract :
Introduction: Mature cystic teratoma is the most common benign ovarian tumour accounting for 20%
cases among all ovarian neoplasm. It is a germ cell tumour. Malignant transformation of an epithelial
component to squamous cell carcinoma is very rare phenomena accounting for only 2% of squamous cell
carcinoma cases. In this case report, we are presenting two cases of squamous cell carcinoma arising in the
mature cystic teratoma.
Case Report: Two women of age 62 and 47 years were presented to the gynaecology OPD with the
complaints of distension and pain in the lower abdomen. On CECT abdomen of both the cases, there were
solid cystic mass seen and the possibility of teratoma was suggested. On histopathologic examination,
diagnosis of a mature cystic teratoma with a component of squamous cell carcinoma was offered.
Discussion: Mature cystic teratoma is frequently seen in young women. Malignant transformation in the
setting of mature cystic teratoma is rare event and is more common among postmenopausal women.
Conclusion: Malignant transformation in mature cystic teratoma carries a poor prognosis and need to be
treated aggressively. Early diagnosis and adjuvant chemotherapy is the only way to increase the chances
of survival of the patient. Mature cystic teratoma, especially if it is presenting in post-menopausal women
is alarming and should be viewed with a high degree of suspicion as there are more chances of malignant
transformation.
Keyword :
Mature cystic teratoma, Squamous cell carcinoma.