Abstract :
Introduction: Round cell tumors are poorly differentiated tumors. Immunohistochemistry is a useful and cost effective approach for differentiation of Malignant round cell tumors. NonHodgkin’s Lymphoma and Ewing Sarcoma are most commonly encountered tumors among them.
Aim: (1) For categorization of round cell tumors. (2) To Study the occurrence and distribution of tumors in different age groups.
Materials and Methods: We studied 141 cases over a period of one year (January 2017 to December 2017). Formalin fixed, paraffin embedded sections of tumors diagnosed on small biopsies as well as resected specimens were taken. Immunohistochemistry was done on cases which were reported as malignant round cell tumors on routine HPE.
Results: Non Hodgkins lymphoma was the commonest among these small round cell tumors comprising 51.77% (73 cases). The next most common tumor was Ewing’s Sarcoma/PNET which had 28 (19.86%) cases. Other were small cell carcinoma of Lung (9.93%), Neuroblastoma, (4.26%) Medulloblastoma (3.54%), Rhabdomysarcoma (2.84%) and Wilm’s tumors (2.84%). We found 18 cases of Neuroendocrine tumors of GIT in which two cases were small cell variant of neuroendocrine carcinoma of GIT (1.42%).
Conclusion: Clinical details, morphology and Immunohistochemistry play a vital role in differentiating malignant round cell tumors.
Keyword :
Round cell tumors, Immunohistochemistry.