Volume :

3

Issue :

4

Abstract :

Two simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of Sertraline Hydrochloride from its tablet formulation. The developed methods are based on formation of chloroform extractable colored complex of drug with alizarin red and tropaeolin ooo. The chloroform extracted complex of drug with alizarin red showed absorbance maxima at 425.0 nm and linearity was observed in the concentration range of 20-90 µg/ml (method-I), with tropaeolin ooo showed absorbance maxima at 485.0 nm and linearity was observed in the concentration range of 3-24 µg/ml (method-II). Results of analysis for both the developed methods were validated statistically and by recovery studies.