Author :
Sanyukta A. Patil, Manjunath S. Somannavar, Deepthy M. Sadanandan, Elizabeth M. McClure, Shivaprasad S. Goudar, Robert L. Goldenberg, Sanyukta A. Patil, Manjunath S. Somannavar, Deepthy M. Sadanandan, Elizabeth M. McClure, Shivaprasad S. Goudar, Robert L. Goldenberg
Volume :
12
Issue :
4
Abstract :
Background: Pregnancy-induced hypertension (PIH) is among the serious obstetric concerns worldwide with stillbirths being one of the potential consequences. Placentas in pregnancies affected by PIH exhibit an increase in anti-angiogenic proteins that could serve as markers of adverse birth outcomes. Use of relevant biomarkers could aid in effective diagnosis, therefore preventing fatal consequences. Our study aimed to explore the association between maternal serum levels of soluble endoglin (sEng) and stillbirths in pregnancies complicated by PIH.Materials and Methods: This case-control study utilized a total of 150 blood samples collected on admission for delivery comprising 50 cases of stillbirths, 50 preterm livebirths (preterm controls) and 50 term livebirths (term controls). The sEng levels were measured in the maternal serum using an enzyme linked immunosorbent assay (ELISA).Results: The sEng levels were markedly elevated in the cases [Median (Q1, Q3): 21 (18,31)] compared to the term controls [Median (Q1, Q3):14 (10,20)] with stillbirth samples demonstrating the highest concentrations of sEng compared to samples from the preterm and term livebirths (p-value
Keyword :
Hypertensive disorders of pregnancy, Stillbirth, Soluble endoglin, Enzyme linked immunosorbent assay, Biomarker.