Abstract :
Introduction: Solid Pseudopapillary tumor (SPT) is a tumor with low malignant potential and comprises
around 1-2% of all tumors occurring in Pancreas. Pseudocyst of Pancreas, Microcystic adenoma,
neuroendocrine tumor and mucinous cystic neoplasm are considered as challenging differentials of SPT.
High suspicion followed by accurate diagnosis is key to management because SPT is known for its good
prognosis and successive cure rate on surgical resection.
Case Presentation: 21-year-old female patient presented with complaints of abdominal pain and
dyspnoea. Imaging studies revealed a retroperitoneal tumor. Surgical resection carried out. Gross
examination of the specimen showed circumscribed lobular brown mass weighing around 468 gm with
a measurement of 15x12x10 cm. On sectioning, the tumor had a variegated appearance containing multiple
cysts varying from 1 - 3 cm in size. Microscopic examination revealed an encapsulated cellular neoplasm
with individual tumor cells arranged in solid, pseudopapillae and cystic patterns. Tumor cells were round
to oval with no distinct nucleoli. Mitotic figures were very few in number. Hyaline globules were noted.
Mucinous changes were seen focally. Occasional areas exhibited clear cell change of tumor cells. Cystic
areas were filled with heamorrhage. Vascular areas were unremarkable. Normal Pancreatic parenchyma
was noted at the tumor edge.
Conclusion: Morphology of SPTs are varied ranging from solid to cystic appearance. No definitive
morphology is identified to differentiate benign from malignant SPT. SPT are known to mimic a wide
range of pancreatic and retroperitoneal lesions that may pose a challenge to diagnostic pathologists as seen
in this case.
Keyword :
Calcified tooth, Dental operating microscope, Maxillary central incisor.