Abstract :
Background: UTIs are am bong the most frequent bacterial infections globally, yet rising resistance and MDR strains complicate management. Demographic factors such as age and gender, along with surgical interventions, may significantly influence resistance. Understanding these associations is vital to guide empirical therapy and strengthen antimicrobial stewardship.Aims and Objective: To analyze antibiotic resistance trends and the prevalence of multidrug-resistant (MDR) uropathogens in urinary tract infections (UTIs), with focus on demographic and surgical associations.Materials and Methods: A retrospective study was conducted at Apollo Rajshree Hospital, Indore, from January–December 2024. Data of 200 culture-positive UTI inpatients were analyzed. Uropathogens were identified using biochemical and automated methods. Antibiotic susceptibility testing was performed by Kirby–Bauer and VITEK II per CLSI guidelines. MDR was defined as resistance to ?3 antibiotic classes. Statistical analysis was done using Jamovi and Minitab, with Chi-square tests applied.Results: Among 200 patients, 53.5% were male and 48.5% elderly. Diabetes (32.5%) and hypertension (26.5%) were common comorbidities. Surgical history was present in 54%, mainly DJ stenting and PCNL. Resistance exceeded 90% for ?-lactams, cephalosporins, and fluoroquinolones. Fosfomycin (40%), Nitrofurantoin (56%), Colistin (54.5%), and Polymyxin-B (55.9%) retained better activity. MDR prevalence was 67.5%, highest in K. pneumoniae (73.4%) and P. aeruginosa (73.9%). MDR showed significant association with male gender, advanced age, comorbidities, and surgical history (p
Keyword :
Urinary tract infection, Antibiotic resistance, Multidrug-resistant uropathogens, Demographic factors, Surgical associations.