Abstract :
Background: Diabetes Mellitus is a metabolic disorder affecting many organs and the leading cause of morbidity and mortality across the world because the disease is insidious. The diagnosis often is delayed and may affect both larger and smaller blood vessels. Prediabetes is a state of a person before the diagnosis of diabetes which is associated with many diabetic complications. The purpose of this study is to find the association of serum magnesium and uric acid levels in prediabetes.
Materials and Methods: It is a case control study where subjects with prediabetes were considered as cases and subjects with normal glucose levels as controls. The subject’s serum glucose levels, serum zinc levels and serum magnesium levels of both the groups was measured and analyzed.
Result: The mean of the Serum Magnesium level in cases was 1.42 ± 0.54 mg/dl and that of controls is 1.93 ± 0.44 mg/dl and the mean of the Serum Uric acid levels in cases among males and females are 7 ± 1.95 mg/dl and 6.63 ± 1.71 mg/dl respectively and that of controls is 5.02 ± 0.98 mg/dl and 4.31 ± 0.87 mg/dl which were statistically significant. The results obtained are in such a way that there is a decreased magnesium and increased uric acid levels in prediabetes.
Conclusion: Hypomagnesemia might be due to defective insulin receptor phosphorylation, decreased glucokinase activity and closing of potassium channels causing insulin resistance or impaired insulin secretion or both. Hyperuricemia would be due to tubular hypertrophy, oxidative stress and inflammation. Finding this relation will help us to prevent progression of prediabetes to diabetes by suitable diet, exercise and life style modifications.
Keyword :
Diabetes Mellitus, Hyperuricemia, Hypomagnesemia, Prediabetes.