Serum lipids in sub clinical hypothyroidism: A retrospective study


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Article type :

Original Article

Author :

Audi Bhagyalakshmi, Amrut Arvindrao Dambal, D Sridevi, Prabhavati Modi, Lakshmi Chaitanya, M Amala Krishna

Volume :

7

Issue :

2

Abstract :

Background: Thyroid hormones are a potent regulator of metabolism, playing a crucial role in regulating energy expenditure and in key physiological mechanisms. Their prominent and well-known role is an increase in basal energy expenditure obtained by acting on carbohydrate, protein and lipid-metabolism. Hypothyroidism is relatively common and is associated with an unfavorable effect on lipid metabolism. Few studies reveal subclinical hypothyroidism to be a risk factor for increased incidence of lipid abnormalities and resulting in cardiovascular abnormalities. Aim: Hence study was taken up to find the association of serum lipids with subclinical hypothyroidism. Methodology: This was a retrospective study conducted in the department of Biochemistry, Malla Reddy hospital. Biochemically identified 102 subjects of Subclinical hypothyroidism subjects between 15-50 years and evaluated for lipid profile were included in the study. In our study, the mean serum total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol expressed in mg/dl were 189.9824.16, 166.48 17.4, 37.62 2.89 and 121.34 27.31mg/dl respectively. 41 subjects out of 102 had higher total cholesterol, triglycerides and LDL cholesterol with lesser HDL cholesterol from the acceptable limits. Conclusion: We conclude that impaired lipid parameters are associated with subclinical hypothyroidism. Hence a regular screening for lipid profile should be considered in subclinical hypothyroidism for early diagnosis, prevention and management of cardiovascular complications.

Keyword :

 TSH, HDL cholesterol, LDL cholesterol, Sub clinical hypothyroidism.
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