Author :
Sulakshana Shridhar Baliga, Anirudh Singh, Padmaja Walvekar, Rajeshwari S Handigund, M S Karishetti, Sulakshana Shridhar Baliga, Anirudh Singh, Padmaja Walvekar, Rajeshwari S Handigund, M S Karishetti
Volume :
12
Issue :
4
Abstract :
Background: Diabetic kidney disease is a critical microvascular complication of diabetes, accounting for 33.6% of the total cases. Diabetic nephropathy occurs due to /chronic hyperglycaemia, causing kidney damage, which is a significant concern. Early detection of diabetic kidney disease can significantly improve morbidity and mortality.Material and Methods: This study was done on 159 already known cases of type 2 diabetes mellitus with no previously documented impaired renal function. Serum Creatinine and Serum Cystatin C was done and eGFR was calculated.Results: In the present study the sensitivity of serum creatinine was 52% and specificity was 91%. The sensitivity of serum Cystatin C 72% and specificity was 100%. Area under curve was 65% for Serum Creatinine and 80% for Serum Cystatin C. When compared to Serum Creatinine and eGFR (rho = -0.6931), there was a significant negative correlation (rho = -0.9794) between serum cystatin C and eGFR. This demonstrates that a decline in eGFR can be detected by a significant increase in Serum Cystatin C levels.Conclusion: With higher Sensitivity and Specificity of Serum Cystatin C, as well as a strong negative correlation between eGFR and Serum Cystatin C, it can serve as a biomarker for early diagnosis of kidney disease among type 2 diabetic patients.
Keyword :
Serum cystatin C, Serum creatinine, Kidney disease, Biomarker.