Abstract :
Objective: Asthma is the most prevalent chronic respiratory disease among children causing considerable morbidity
and mortality.
Interleukin-4 (IL-4) is an important mediator of inflammatory cytokines derived from T helper and mast
cells. It mediates essential pro-inflammatory functions in asthma such as induction of the IgE isotype switch,
enhancing of eosinophil migration across endothelium, expression of vascular cell adhesion molecule-1 (VCAM-1),
mucus secretion, and differentiation of T helper type 2 lymphocytes leading to cytokine release. The aim of our study
was measuring the serum IL-4 and IgE levels in bronchial Asthma in Syrian children at different stages of the Asthma
disease and in exacerbations, as biomarkers in clinical evaluation of Asthma patients and studying the correlation
between IL-4 and IgE levels in order to determine their effects in asthma.
Methods: This study included 88 individuals: 38 children with acute Asthma exacerbations (E Asthma), 30 children
with stable Asthma (S Asthma), and 20 healthy controls. The serum IgE and IL-4 levels were assessed with ELLSA
technique.
Results: The results showed that IL-4 and IgE levels were significantly increased (p
Keyword :
Asthma, serum IgE, serum IL-4, Acute Exacerbation