Abstract :
Mixing process is widely used in pharmaceutical industry to blend different API as well as additives to prepare solid
dosage formulations. If mixing is not done properly there is always chance of dose variation and content uniformity
variations. Due to this, the present paper deals with the study of the effect of mixing time, speed and % of one
compound in another on the effectiveness of the process. Statistical analysis technique was used to understand the
interaction effect of variables instead of one factor at a time. A 23 factorial design was applied to investigate the
combined effect of three formulation variables, time (A), mixing speed (B) of and the % amount of diclofenac
sodium (C) used. The mixing index (MI) taken as responses (Y). Polynomial equations were used to relate each
response to the factors affecting it. Counter plots and response surface plots were drawn and an optimum
formulation was selected using the desirability function
Keyword :
Powder mixing, Mixing index, Response surface plots, Contour plots