Abstract :
Cardiovascular disease (CVD) is the leading cause of death worldwide.Atheroscelerotic cardiovascular disease(ASCVD) is also a leading
cause of death and disability. Statins can reduce the risk and prevent heart
diseases. One of the best studied medication and in randomized controlled
trials have been proven to reduce the no of Heart attacks and stroke even in
individuals with normal cholesterol levels. A small no of individuals may
develop Diabetes on statins.The benefit from lowering the risk of death, heart
attack and stroke are likely to outweigh the development of diabetes in those
individuals. The beneficial effects of statins may not only be due to the
cholesterol lowering effects but also due to cholesterol independent or
pleiotropic effects. These benefits include endothelial protective functions,
enhancing stability of atherosclerotic plaques and inhibiting vascular smooth
muscle proliferation and platelet aggregation. It remains to be seen to what
extent these pleiotropic benefits of statin therapy can be attributed beyond cholesterol lowering.
Keyword :
Statins, Cardiovascular Disease, Dyslipidemia, Atheroscelerosis, Cholesterol.