Abstract :
The present work aimed to develop and validate spectrophotometric methods for simultaneous estimation of
rabeprazole sodium and aceclofenac in a pure and capsule dosage form. A simple, sensitive, spectrophotometric
method in UV region has been developed for the simultaneous estimation of Rabeprazole sodium and Aceclofenac in
bulk and semi dosage form (Capsule). Standard solution of Rabeprazole sodium shows maximum absorbance at 283
nm and Aceclofenac shows maximum absorbance at 276 nm. Beer’s Lamberts law is obeyed in concentration range
10-60 µg/ml for Rabeprazole with regression, slope and intercept of 0.991, 0.0918 and 0 respectively while for,
Beer’s Aceclofenac Lambert law is obeyed in concentration range 10-60 µg/ml with regression, slope and intercept
having 0.9984, 0.2069 and 0.0253 respectively. Method was validated for linearity, range, accuracy, precision,
recovery studies and interference study of mixture. All these parameters showed the adaptability of the method for
the quality control analysis of the drug in bulk and in combination formulations
Keyword :
Rabeprazole sodium, Aceclofenac, Simultaneous equations, absorbance interference study.