Abstract :
Objective: To study the effect of anti-oxidative compounds on progression and management of Parkinson’s disease (PD).
Design: An open randomized controlled trial.
Setting: The study was conducted in the neurology clinic of All India Institute of Medical Sciences, New Delhi, India.
Subjects: A total of 125 subjects were randomly selected out of which 35 patients either declined or dropped out.
Interventions: 90 PD patients were assigned randomly either to the case or control group. Coenzyme Q10-90mg, Vitamin C-250mg & E-200 I.U./day were administered to the case group for six months duration and anthropometry, dietary intake, and neurological status were assessed at the beginning and end of the six months in both the groups.
Results: Difference in the total carbohydrate, protein and fat intake at the end of sixth month was found to be extremely statistically significant at p > 0.001. Unified Parkinson’s disease rating scale (UPDRS) total scores of PD patients in the case group depicted slight decrease in total UPDRS scores from 29.17 14. 01 at baseline to 24.58 14.32 but the scores were not found to be statistically significant (p > 0.05).
Conclusions: It is reasonable to expect that diet and multiple antioxidant supplementation in PD patients should be able to prevent disease progression. However, large-scale clinical trails are required to confirm these trends and determine the exact dosages that are likely to be effective.
Keyword :
Parkinson’s disease, Supplementation, Antioxidants, Nutritional status