Abstract :
Aims: Study aims to reduce the emergence agitation post operatively and improve the quality of recovery
after nasal surgery which in-turn reduce the hospital stay and in-hospital mortality.
Settings and Design: Prospective, randomized, double blind study
Material and Methods: After institutional review board approval and informed written consent from
patients, seventy patients undergoing nasal surgery were selected & randomized into two groups. The
dexmedetomidine group (Group D, n=35) received dexmedetomidine infusion @ rate of 0.4 mg/kg/hr
from induction of anaesthesia until extubation, while the control group (Group C, n=35) received volumematched
normal saline infusion as placebo. Induction of anaesthesia was done using Propofol (2 mg/kg) and
fentanyl (1 mg/kg). Maintainance of anaesthesia was done using inhalational sevoflurane & inj.vecuronium.
The incidence of agitation, haemodynamic parameters, and recovery characteristics were evaluated during
emergence. Patients were assessed for quality of recovery using a 15-item quality-of-recovery questionnaire
(QoR-15) 24 hr after surgery.
Statistical Analysis: Data were analysed by using unpaired t -test, Chi-square test.
Results: The incidence of agitation was lower in group D than group C(22.8% vs 51%). HR and MAP
were comparable in group D & group C. Extubation time & grade of cough during emergence were similar
between the groups. QoR-15 score was significantly more in group D compare to group C at 24 hour after
surgery.
Conclusions: Intraoperative infusion of dexmedetomidine decreased incidence of agitation & improved
quality of recovery after nasal surgery.