Abstract :
Notch signal transduction pathway is one of the important pathways that affect the fate of cells. Adjacent cells
transmit signals through Notch receptors to regulate the differentiation, proliferation and apoptosis of many kinds of cells, including stem cells. Affects organ formation and morphogenesis. Gene mutations of some molecules in Notch signaling pathway are related to the occurrence and development of many diseases. On the basis of in-depth study of Notch signal transduction pathway, using it as a target to design drugs for the treatment of related diseases, including cancer, CADASIL and other hereditary diseases, or the development of stem cell medical techniques. Surgical treatment of Alzheimer's disease (disease,AD), Parkinson's disease, diabetes mellitus and other cellular tissue dysfunction or impaired diseases has important scientific significance and application value.
Keyword :
Notch; neoplasms; genetic diseases; stem cells