Abstract :
Differentiated somatic cells can be reprogrammed into induced pluripotent stem cells (iPS cells) by introducing
specific transcription factors. This technique avoids immune rejection and ethical problems in stem cell research.
A great revolution in the fi eld of science. As with embryonic stem cells (ES cells), iPS cells are able to self-renew
and maintain undiff erentiated state. In vitro, iPS cells can be induced to diff erentiate into a variety of mature cells, therefore, iPS cells in theoretical research and clinical applications are extremely valuable. IPS cell diff erentiation and transplantation in the treatment of blood diseases have a great use, iPS cells can treat nervous system diseases, to provide in vitro disease model, to study the mechanism of disease formation, screening new drugs and the development of new to provide a new treatment The The use of iPS cells as a nuclear donor cell, with the appropriate receptor cells after fusion can be directly obtained transgenic animals. Not only can improve the genetic nature of animals, but also can break the boundaries of species and get the new animal traits that cannot achieve by using traditional mating methods. The research of iPS cells has been widely concerned, and it is the research hotspot in cell biology and molecular biology. In this paper, the defi nition of iPS cells, the acquisition of iPS cells, the history of development, the signifi cance of research, the progress of research, the application of iPS cells, and the problems of iPS cells were reviewed.
Keyword :
Inducible pluripotent stem cell; Embryonic stem cell; Transcription factor reprogramming differentiation