Abstract :
Background: Helicobacter pylori is one of the most important causes of the varied spectrum of gastroduodenal diseases. It is important to have a collaborative approach between clinicians and pathologists for early initiation of treatment in patients and control the progression of the disease.
Aims: To evaluate the clinico-histopathological spectrum of gastroduodenal diseases with respect to Helicobacter pylori infection and provide recommendations for reporting and management of the same.
Materials and Methods: All patients of chronic dyspepsia not responding to conventional treatment were subjected to endoscopy, and mucosal biopsy samples were collected. A rapid urease test (RUT) and histopathology was performed on these samples. A histopathological evaluation was done with special reference to the Updated Sydney System for reporting of chronic gastritis.
Results: The specificity, sensitivity, positive predictive value, negative predictive value, and diagnostic accuracy of RUT were 97.22%, 94.04%, 98.75%, 87.5%, and 95%, respectively. The specificity, sensitivity, PPV, NPV and diagnostic accuracy of endoscopy were calculated as 98.68%, 88.5%, 95.83%, 96.15% and 96.07% respectively.
Conclusion: A clinicopathological approach for diagnosis of Helicobacter pylori associated gastroduodenal diseases which includes clinical assessment, endoscopic evaluation, RUT and histopathological analysis is of prime importance for effective management of such patients.
Keyword :
Diagnosis, Helicobacter pylori, Histopathology, Endoscopy