Abstract :
Introduction: Diabetic patients are prone to develop coronary heart disease, stroke and even microvascular
complications like diabetic nephropathy, retinopathy and neuropathy. Chronic hyperglycemia is considered
an important etiological factor leading to such complications. Diabetic nephropathy is one of the most
common causes of chronic kidney disease (CKD) in India. For staging of CKD, estimation of the
glomerular filtration rate (GFR) is necessary. One of the commonly used equations to estimate GFR (eGFR)
is the equation from the Modification of Diet in Renal Disease (MDRD) study. This study was carried out
to assess correlation between glycemic control of type 2 diabetic patients, assessed by HbA1c, with their
renal impairment status, checked by eGFR.
Materials and Methods: 50 patients of type 2 Diabetes Mellitus (T2DM) and 50 non diabetic controls
were enrolled for the study. Their fasting blood sugar (FBS), serum creatinine and HbA1c level were
measured and eGFR were calculated using MDRD equation. HbA1c levels were compared with eGFR
values.
Result: HbA1c levels were significantly correlated with eGFR in diabetic patients. But no significant
correlation was found between these two parameters in non diabetic controls.
Conclusion: Renal function impairment due to diabetic nephropathy can be predicted by measuring HbA1c
levels in diabetic patients and proper measures can be planned to delay significant renal damage.
Keyword :
eGFR, HbA1c, T2DM.