Abstract :
The danger for thromboembolic disorder is raised in long-term stayers of infant acute lymphoblastic
leukemia (ALL) because of endothelial malfunction (ED). Adverse endothelial malfunction occurs through the acute
stage of disease. The levels of von Willbrand factor antigen (VWF:Ag) increase in neoplastic diseases and appear
from harmful changes in the endothelium. Our purpose of this study is to verify plasma levels of (VWF:Ag) in
children who diagnosed ALL recently,and compare them with peripheral blast cells (PBs) and chemotherapy. Our
study involved thirty patients with acute lymphoblastic leukemia (17 males and 13 females) with their ages from 2
to 12 years. VWF:Ag levels were analyzed by enzyme linked immunosorbent assay (ELIZA) and measured at the
start of diagnosis (D0) and at day (D35) of chemotherapy for 30 ALL children with and without peripheral blast cells
(PBs). Our results indicated that patients with PBs had higher median plasma VWF:Ag concentrations than
individuals without (99.69 ±72 ng/ml vs 64.18 ± 40.14ng/ml, P
Keyword :
Von Will brand Factor, Peripheral Blasts, Acute Lymphoblastic Leukemia.