Abstract :
Aim: The aim of this study was to investigate the ameliorative effects by the intervention of Moringa
Oleifera seed oil on the damage to frontal cortex of rats by cadmium and herbal alcoholic beverage.
Materials and Method: Eighty Wistar rats (73-151g,n=10)grouped as follows: A Control;B1(Cadmium)
;B2(Cadmium Moringa seed oil) ;C1(Herbal alcoholic Beverage);C2(Herbal alcoholic Beverage moringa
seed oil);D(Cadmium Herbal alcoholic beverage);E(Cadmium Herbal alcoholic beverage Moringa seed
oil) and F(Moringa seed oil) for four weeks followed by histological studies.
Results: The histoarchitecture of the frontal cortex was characterized by pyknosis of nuclei which resulted
in dissolution of Nissl substance. Activation of astrocytes were evidence in group B1, B2, C1, C2 and D
which were exposed to cadmium and HAB while those of groups B2, C2 and E showed ameliorative effect
that were evident in reduction in pyknotic neurons and reduction of activated astrocytes.
Conclusion: Based on the results, it can be deduced that Moringa Oleifera seed oil has neuroprotective
properties.
Keyword :
Cadmium, frontal cortex, Moringa, Beverage, Nissl substance