Abstract :
Breast oncogenesis is a multistage process that involves epigenetic and genetic changes.
Epigenetics is outlined as reversible changes in gene expression, with no alteration in gene sequence.
DNA methylation, histone modification, and nucleosome transformation are the foremost epigenetic
changes that may get dysregulated in breast cancer. Epigenetic silencing of tumor suppressor genes
(TSGs) is reversed by varied molecules as well as natural compounds like polyphenols which will act
as a hypermethylation agent. Nowadays, much of the research is going in the direction of natural and
dietary compounds and attempting to search out novel and extra effective medical aid for the breast
cancer patients. In this literature, few vital natural chemical compounds effective against the breast
oncogenesis with their mode of actions are discussed. Such chemicals act as an analytical and
prognostic tool in breast cancer due to their role in epigenetic regulation.
Keyword :
DNA methylation, Epigenetics, Gene expression, Oncogenesis, Tumor suppressor gene.