Abstract :
Two simple UV-Spectrophotometric methods have been developed for estimation of trazodone HCl (TZH)
in bulk and pharmaceutical formulation form by using Zero order UV spectrometric absorbance method
(method I) and Zero order UV spectrometric method using area under curve technique (method II). Water
was used as solvent. In these Method ? max was found to be 246.0 nm of TZH and AUC between two
wavelengths 235.20 nm – 256.60 nm. In both method Linearity in the concentration range of 05-35 mg/ml
(r2>0.99)for TZH. Proposed methods were applied for oral dosage and amounts of TZH estimated by
method I were found to be 99, by Method II were found to be 98.80 respectively. Both these methods were
validated statistically and by recovery experiments.
Keyword :
Trazodone hydrochloride(TZH), UV spectrometric, Zero order, AUC.