Abstract :
Tectona grandis has been claimed to be useful in treatment of
microbial and fungal infections and the current literature survey
revealed that no systematic approach has been made towards
documentation of this claim. The currently available synthetic
antimicrobial agents are associated with numerous serious side
effects like hypersensitivity, crystalluria, photosensitivity, hepatic
and renal damage, ototoxicity, neurotoxicity etc. These adverse
effects either restrict the continuation of therapy or demand for
additional drug/s to combat them. This in turn indicates the need
of alternative value addition therapy. In light of this, Methanolic
and Petroleum ether extract of Tectona grandis was screened for
its antifungal activity by using fungal culture but none of extracts
were found to be significant in this regard. The claim mentioned in
an ancient period may be of value especially in absence of today’s
effective antifungal agents. As far as today’s minimum standard
required, it cannot be promoted as antifungal as per these
observation.
Keyword :
Tectona Grandis, Methanolic and petroleum ether extract, antifungal activity, Hypersensitivity,ototoxicity,Nephrotoxicity.