Abstract :
Introduction: BPD (bronchopulmonary dysplasia) is the most common complication of preterm birth for
all gestational ages. The phenotype seen with BPD is the end result of a complex multifactorial process in
which various pre-and postnatal factors compromise normal development in the immature lung. The aim
of this study was to monitor the pulmonary function in preterm infants with bronchopulmonary dysplasia,
and to declare the hypothesis that BPD has different phenotypes, that could be detected by iPFT during
their initial NICU stay.
Materials and Methods: This is a prospective study, in the period from Feb 2015 till April
2018. It includes 32 preterm infants (gestational age
bronchopulmonary dysplasia (BPD). Pulmonary Function Test (PFT) was done for all patients one day
before discharge from NICU.
Results: the median gestational age at birth was 29.6 weeks ([IQR], 27.6-28.9) and the median birth weight
was 1500 g (IQR, 945-1760). At the time of iPFT, the median postmenstrual age 44 weeks (IQR, 39-47), the
median weight was 4.25 kg (IQR, 3.25-5.350). There were 19 patients (60%) with obstructive, 9 patients
(29%) with mixed, 4 patients (11%) with restrictive phenotypes.
Conclusions: our findings reveal that BPD has 3 distinct phenotypes. The different phenotypes of BPD
must be taken into consideration in the management of such patients for better outcome. Future researches
are needed in a larger scale to define accurately the bronchopulmonary dysplasia phenotypes
Keyword :
Bronchopulmonary dysplasia, Infant pulmonary function, Premature.