Abstract :
Propranolol is a beta-blocker.3 Beta-blockers affect the heart and circulation blood flow through arteries and veins . Propranolol is a nonselective beta-adrenergic receptor blocker beta-blocker that is widely used for the therapy of hypertension, cardiac arrhythmias, angina pectoris and hyperthyroidism. Propranolol has yet to be convincingly associated with clinically apparent liver injury and is often used in patients with liver disease and cirrhosis. Traditional medication delivery methods, such as pills, capsules, liquids, powders, and intravenous needles, are often inefficient or invasive and can lead to undesirable side effects8. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. The present study of preparation of Propranolol base from hydrochloric salt, which results white amorphous powder of Propranolol base and characterization of different parameters is done for its physiochemical properties. Also preparation of monolithic Transdermal patch from Propranolol hydrochloride and evaluation of different physical parameters.
by Vishal N. Kushare "Preparation of Transdermal Patch from Propranolol Base Prepared from Hydrochloric Salt and Evaluation of its Physical Parameters"
Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-1 , December 2018,
URL: http://www.ijtsrd.com/papers/ijtsrd18997.pdfPaper
URL:http://www.ijtsrd.com/other-scientific-research-area/other/18997/preparation-of-transdermal-patch-from-propranolol-base-prepared-from-hydrochloric-salt-and-evaluation-of-its-physical-parameters/vishal-n-kushare
Keyword :
Propranolol Hydrochloride, Solubility, Spectroscopic analysis, Transdermal Patch, Skin, Permeation.