Abstract :
Cephalexin is semisynthetic first generation cephalosporin having activity against gram positive and
gram negative bacteria. As it is bitter drug work has been undertaken to prepare taste- masked mouth
dissolving tablets of cephalexin by incorporation of drug encapsulated microspheres into the tablets
for use in pediatrics and also in patients experiencing difficulty in swallowing like geriatrics.
Microspheres of cephalexin were prepared by solvent evaporation method using Eudragit E 100 and
were characterized with regard to percentage yield, drug content and percentage entrapment, particle
size, surface features, in-vitro drug release and taste. The microspheres of cephalexin having a drug:
polymer ratio of 1:0.5 are tasteless, free flowing and spherical in shape.
Keyword :
Cephalexin, Eudragit, Solvent evaporation, Microspheres