Volume :
1
Issue :
2
Abstract :
The objective of the present work is to develop and characterizes oral sustain release matrix tablets of Repaglinide. Repaglinide is practically insoluble in water so it is suitable to develop sustained release matrix tablet using hydrophilic polymers. Repaglinide is anti-diabetic drug used extensively in the treatment of diabetes type II. The natural polymers like carrageenan, chitosan, gum karaya, Bhara gum were utilized in the formulation of matrix tablets containing Repaglinide by wet granulation technique and evaluated for its drug release characteristics. Granules were prepared and evaluated for its physical properties and shows satisfactory results. Formulation was optimized on the basis of acceptable tablet properties (hardness, friability, drug content and weight variations), in vitro drug release and stability studies. All the formulations showed compliance with Pharmacopeial standards. The in vitro release study of matrix tablets were carried out in phosphate buffer pH 6.8 for 12 hr. Among all the formulations, F2 with shows 100% better controlled release at the end of 12 hrs when compared to other formulations. The release data was fitted to various mathematical models such as, Higuchi, Korsmeyer-Peppas, First-order, and Zero order to evaluate the kinetics and mechanism of the drug release. The drug release of optimized formulations F2 follows zero order kinetics and the mechanism was found to be diffusion coupled with erosion (non-Fickian diffusion). The stability studies were carried out according to ICH guideline which indicates that the selected formulations were stable.