Volume :
3
Issue :
1
Abstract :
Deferasirox is an oral iron chelater used to reduce chronic iron over load in patients who are receiving long term blood transfusion for condition such as beta-thalassemia. In this study deferasirox drug were formulated by direct compression. Six formulations of effervescent tablets were prepared by using different concentrations of effervescent agents to get desired release profile of reference product. Drug - Exciepient compatibility was studied by FT-IR spectral analysis. Effervescent tablets of deferasirox drug were prepared by using various excipients .Pre compressive parameters like carr’s index of all formulations between 22.54 ± 0.1 to 11.68 ±0.19, indicates passable compressibility index. Angle of repose of formulations from 37.34±0.04 to 33.50 ±0.14 i.e.., it declares that all are possessing good flow properties and hausners ratio of all formulations was 1.29±0.09 to 1.12±0.10 which satisfies the limits of compressibility. Post compressive parameters like weight are within limits .Hardness test of all the formulations from 9.3± 0.13 to 10.3 ±0.45 kg/cm2 .All the evaluation parameters were under acceptable ranges. The in vitro drug dissolution studies were carried out for the formulations in pH6.8 phosphate buffer .Dissolution profiles of all trials were done among all the formulations F6 better release. Stability studies were carried out for optimized formulation as per ICH guidelines.