Abstract :
Background: Even when there is enough oxygen available, cancer cells meet their energy requirements by increasing glucose intake, glycolysis rate, and lactate generation. Otto Warburg proposed this process, which is known as the Warburg effect. A recent method of drug discovery includes developing medications that interfere with glucose consumption and aerobic glycolysis, or lactate production in cancer cells. Curcumin (C), Quercetin (Q), Ellagic acid (E), and Resveratrol (R) were examined in U87 cells for their ability to induce cytotoxicity at certain concencentrtions, as well as modulate lactate-pyruvate metabolism.
Results: All the tested compounds and their combinations such as C E, C Q, C R and Q R have exhibited, dose-dependent cytotoxic effect against U87 Glioma cells. Besides, the compounds and their the combination (except ellagic acid) have modulated glucose intake, lactate-pyruvate, and NADH/NAD ratio in U87 Glioma cells.
Conclusions: Phytocompounds those modulate cellular metabolism in cancer cells are currently unknown. Our findings imply that the phytocompounds used in the study are involved in cancer cell metabolic reprogramming and have cytotoxic properties. These substances could be used for prevention and treating cancer.
Keyword :
U87 cells, Glioma, Warburg effect, Lactate-pyruvate