Abstract :
HA7 Choorna, composed of Strychnos potatorum, Curcuma longa, Coscinium fenestratum, Cassia fistula, Terminalia chebula and used for pyospermia in sub fertile male, was analyzed in vitro to find out its antioxidant capacity, phytochemical properties, availability of bioactive components and heavy metal contents. Pyospermia, the finding of more than 5 seminal pus cells/ high power field, has a negative relationship with seminal parameters hence the male fertility. Thus, the attention on pyospermia is important as an etiology of male subfertility. The HA7 Choorna was selected here due to its heavy usage against pyospermia in Ayurveda. In the assay, the components, tannins, flavonoids, terpenoids, phenol were found. Comparatively drug had a satisfactory antioxidant capacity. The heavy metals Pb, Cd, As, Hg were below the reference level. Two chemical compounds (Rf = 0.75 and 0.76) were found under the Chromatography/TLC. Thus, the drug has natured a good antioxidant level which can fight against the bad effect of free radicle synthesized in pyospermia due to the finding of phytochemicals in it. The drug is safe from mentioned heavy metals. Finally, upon the result the other studies such as microbiological, phytochemical, toxicological studies should be carried out on drug to ascertain its safety, efficacy.
Keyword :
male infertility; pyospermia, anti-pyospermic drug, phytochemicals, antioxidant, metals