Abstract :
Pheochromocytoma is a rare neoplasm arises from adrenal medulla composed of chromaffin cells that
produce catecholamines. Most are sporadic tumors that present in the fourth and fifth decade of life.
Classic triad of episodic headaches, sweating and tachycardia present in about 30%, while hypertension
is present in almost 90 % of cases. Clinical suspicion with laboratory testing and imaging for
confirmation. Histopathological examination is gold standard, but no single biomarker or histologic
feature predicts malignancy. Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) provides
prognosis based on histologic features. Five patients of pheochromocytoma with PASS score are
described with the aim to represent a rare neoplasm. They are positive for chromogranin, synaptophysin
and S100
Keyword :
Pheochromocytoma, Adrenal gland, PASS