Abstract :
Pharmacogenomics (PGx) — the analysis of the ways in which genetic variation affects drug response — is increasingly transitioning from research to standard clinical practice. Increasing evidence, carefully curated implementation guidelines, and regulatory endorsement now substantiate the use of genotype data to tailor therapy for many of the most widely used drugs. Despite obvious advantages (enhanced efficacy, reduced adverse drug reactions), there are still barriers: disparate test quality, uneven reimbursement, low clinician familiarity, and dispersed clinical decision support. This brief communication provides an overview of the state of clinical pharmacogenomics, identifies successes, and challenges of implementation, and provides useful suggestions for implementing PGx into daily practice.
Keyword :
Pharmacogenomics, Personalized medicine, Clinical implementation, Adverse drug reactions, Precision therapeutics, Pharmacogenetic testing, Genomic medicine