Abstract :
The aim of the present study is to predict the pharmacological and toxicological activities of a novel
polyherbal formulation (PHF) and also to verify its anticancer properties using an In Silico tool called PASS
(Prediction of Activity Spectra for biologically active Substances) by which we can predict the activities
theoretically. The PASS software which has a database predicts about 3750 pharmacological and 2000 toxicological
activities based on its structural activity relationship. The predominant compounds present in the PHF were
determined using GC-MS (Gas Chromatography – Mass spectrometry). In our study we have used this software to
predict the anticancer property of the polyherbal formulation and found that it has potential to act as an anticancer
agent with minimal side effects. Further in vitro and in vivo studies are required to validate these results.
Keyword :
Polyherbal formulation, Anticancer, PASS, in silico.